![]() Where 60 represents MW of urea and 14*2 MW of urea nitrogen. Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L United States, Mexico, Italy, Austria, and Germany). OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. Acute kidney injury (AKI), previously called acute renal failure (ARF), denotes a sudden and often reversible reduction in kidney function, as measured by glomerular filtration rate (GFR).123 However, immediately after a renal insult, blood urea nitrogen (BUN) or creatinine (Cr) levels may be within the normal range, and the only sign of AKI may be a decline in urine output. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. Severe metabolic acidosis, which affects protein metabolism, may contribute to a high BUN:creatinine ratio. if creatinine is US 4, BUN will be around 80-96). The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. Since BUN is affected by dietary intake, if your cat is eating a higher protein diet, this ratio will be higher, with 18:1 or 20:1 not unusual (e.g. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. Interpretation īUN is an indication of renal (kidney) health. It is not considered as reliable as creatinine or BUN/creatinine ratio blood studies. The test is used to detect renal problems. Based on a normal female range for serum creatinine of 45 to 90 mol/l (0.511.02 mg/dl), 24 this equates to mean serum creatinine values of 56 mol/l (0.63 mg/dl), 52 mol/l (0.59 mg/dl), and 54 mol/l (0.61 mg/dl) in sequential trimesters, whereas serum creatinine values greater than 76 mol/l (0. Individual laboratories will have different reference ranges, as the assay used can vary between laboratories. Normal human adult blood should contain 6 to 20 mg/dL (2.1 to 7.1 mmol/L) of urea nitrogen. The liver produces urea in the urea cycle as a waste product of the digestion of protein. 6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood. ![]()
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